In vitro cytotoxicity of Aspilia pluriseta Schweinf. extract fractions

Abstract Objectives We and others have shown that Aspilia pluriseta is associated with various biological activities. However, there a lack of information on its cytotoxicity. This has created an gap about the safety A. extracts. As extension to our recent publication antimicrobial activity phytochemical characterization root extracts, here we report cytotoxicity tested solvent fractions. evaluated potential these extract fractions Vero cell lines by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results show all (except methanolic fractions) had cytotoxic concentration values killed 50% cells (CC 50 ) greater than 20 µg/mL selectivity index (SI) 1.0. Taken together, demonstrate that, fractions’ earlier reported bioactivities are within acceptable selective limits. finding scientifically validates use in discovery safe therapeutics agents.